Forum: Schizofrenia

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Biochemistry of Undermethylation

The undermethylation can lead to a number of deficiencies in nutrients throughout the body. Some researchers believe that if a person is a poor methylator, they are likely to have high levels of histamine, reduced zinc, and a high basophil count.

High histamine: It is thought that a metabolic imbalance occurs when a person isn’t capable of sufficient methylation, leading to abnormally high histamine (e.g. 70 ng/ml).

Low zinc: Some individuals who are chronically undermethylated tend to have zinc deficiencies.

Low copper: Those with poor methylation ability tend to have low levels of copper.
High Basophil count: This is often detected in blood tests and is associated with infections and allergic reactions. If levels exceed 50 cells/cu mm, there’s a better chance of undermethylation.
Low homocysteine: Homocysteine is a molecule that’s created during the process of methylation. Therefore it makes perfect sense that lowered homocysteine would be correlated with undermethylation.
High heavy metals: Proper methylation is thought to help detoxify the body of heavy metals and toxins. If a person is undermethylated, some speculate that they may have increased build-up of heavy metals.

Undermethylation Symptoms

Keep in mind that if you are suffering from undermethylation, you may not experience every symptom on this list. There are different genetic polymorphisms of the MTHFR gene as well as other factors that may dictate your experience. Below is a collective list of symptoms that people with undermethylation tend to exhibit.

Addictions: Those who are considered undermethylators may be more likely to battle addictions and/or have addictive personalities.

Competitive: It is believed that many undermethylators are extremely competitive in sports, business, and other facets of life. Competition is a notable signal that a person may not have a sufficient methylation process.
Concentrative endurance: Some individuals who are suffering from undermethylation may have a difficult time maintaining focus for prolonged periods of time. In other words, their concentration ability may wane quicker than average.
Delusions: Certain individuals that fall into the undermethylation diagnosis may experience delusions or beliefs that aren’t based in reality. While these generally are not severe, then can interfere with the accuracy of a person’s perception of reality.

Headaches: Some researchers believe that undermethylation may cause physical symptoms such as headaches.

High achievement: One characteristic (rather than symptom) of people with low levels of methylation is that of accomplishment and achievement. Many individuals considered top athletes, CEOs, and professionals may be fueled in part by undermethylation.

High libido: A person may be highly interested in sex and/or have a higher than average “drive” compared to others.

Obsessive compulsive: Undermethylation may provoke symptoms of OCD or other obsessive tendencies. In fact, someone may actually get diagnosed with obsessive-compulsive disorder as a result of their methylation deficiency.

Oppositional defiance: Another common finding is that those displaying signs of oppositional defiant disorder (ODD) tend to also have undermethylation. While this isn’t a very common diagnosis, it is thought to be related to undermethylation.

Inner tension: While a person who is an undermethylator may appear to exhibit a calm demeanor, they may be filled with inner tension.
Low pain tolerance: Individuals with undermethylation tend to have a poor tolerance to any sort of pain.
Perfectionism: Another trait of undermethylators is that of perfectionism. They aren’t satisfied unless tasks are completed in accordance to their specific methodology. They may be intolerant to less-than-perfect outcomes.
Phobias: Certain phobias or irrational fears may be caused in part by undermethylation.
Ritualistic behavior: Those who are undermethylated may engaged in ritualistic behavior with rigid schedules. They may have specific daily rituals to which they must adhere.
Seasonal allergies: It has also been suggested that allergies may be stronger among undermethylators, particularly during seasonal transitions. This may be related to naturally elevated levels of histamine, leading to more pronounced reactions.

Self-motivated: A person who is undermethylated may be highly self-motivated in both school and work functions. They may not need any outside inspiration or encouragement to complete their work, they are fuelled internally by themselves.

Social isolation: Some individuals with undermethylation may isolate themselves from others and prefer to be left alone, especially during the completion of work.


Strong willed: Another characteristic that is found among those who are undermethylated is that of a strong will.

Biochemistry of Overmethylation

Overmethylation is the polar opposite of undermethylation. If you are overmethylated, you will likely have elevated levels of serotonin, low levels of histamine, and likely a low count of absolute basophils. Additionally you may discover high levels of copper, but low presence of zinc and histamine throughout the body.

High copper: Abnormally high levels of copper are generally present among those who exhibit overmethylation.

Low basophil count: In cases of overmethylation, basophil count tends to be depressed, meaning theres less likelihood of an allergic reaction.

Low histamine: Overmethylation results in the reduction of histamine, making it completely unnecessary to use an over-the-counter antihistamine.

Low zinc: Another common finding among those who are overmethylators is low levels of zinc.
Overmethylation Symptoms

Below is a list of possible symptoms that you may experience during overmethylation. Understand that overmethylation will not necessarily cause every single symptom on the list and that severity of each symptom is highly subject to individual variation.

ADHD: Those who are overmethylators may have attention deficits and may have been previously diagnosed with ADHD.

Anxiety: In some cases, the overmethylation can lead to increased levels of anxiety and susceptibility to panic attacks.
Artistic: Some sources have suggested a link between artistic and musical pursuits and overmethylation. Whether this is accurate is subject to debate.

Depression: Those with overmethylation may become depressed as a result of high levels of serotonin, lack of motivation, and accomplishment.

Dry skin: It has also been speculated that in those who are overmethylated tend to be more susceptible to bouts of dry skin.

Food sensitivities: If you are an overmethylator, you may notice that you are highly sensitive to certain foods and/or chemicals.

Frustration: Another sign among overmethylators is rampant frustration or becoming easily frustrated in seemingly benign situations.
High pain threshold: Unlike those who are poor methylators, overmethylation is associated with a higher pain tolerance.

Low libido: Another symptom of overmethylation is that of a decreased sex drive. They may be considerably less interested in sex than average.

Low motivation: The general tendency among overmethylators is that of deficient achievement in workplace or competitive settings. This is often a direct result of the motivational deficit that may be a byproduct of overmethylation.

Nervousness: This ties into the generalized anxiety that a person may experience as a result of the overmethylation.

Obsessions: Some have suggested that individuals with overmethylation may demonstrate clear obsessions, but they aren’t usually accompanied by compulsions.

Overweight: Those who are overmethylated may be more likely to pack on weight in part due to motivational deficits and depression.

Paranoia: Among those who are strongly affected by overmethylation, paranoid thoughts, and possibly auditory hallucinations may emerge.

Restless legs: Another possible symptom that you may experience if you’re dealing with too much methylation is restless legs.

Self-imposed isolation: Those who isolate themselves from others may do so in part as a result of depression and or anxiety from overmethylation.

Self-harm: Researchers believe that among those who commit acts of self-harm and mutilation, overmethylation tends to occur.

Sleep disorders: Those with sleep problems may be more likely to have overmethylation.

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